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Current Project
Lying awake of insomnia: towards a neurobiology of broken nights and sound sleep (NWO project).
The neurobiology of vigilance disturbances is hardly known. Why do so many people complain of poor sleep even if their polysomnography suggests otherwise, as in 'sleep-state-misperception': Why do others sleep sound and wake up well-rested even during periods of limited sleep or stress? At what threshold of habitual sleep-restriction do health consequences like fatigue and obesity become a risk? Are genetic differences involved and, if so, in what neuronal signaling pathways? (from NWO project description).
Previous Projects
Beta oscillations correlate with probability of perceiving rivalrous visual stimuli.
Visual illusions are the key to unravel the mechanisms underlying visual perception. A remarkable case of visual illusion is illusory motion reversal (IMR, see an example from Dr. VanRullen's webpage). For most of the viewing time, a rotating wheel is perceived to move in the actual motion direction, but occasionally (5-20% of the time) it appears to rotate in the opposite direction.
Previous research supports the view that this illusion is the result of the competition between neuronal groups encoding opposite motion directions. A recent EEG experiment indicates that the likelihood that one of these neuronal groups will drive perception is reflected in the oscillatory activity in the beta (14-30 Hz) frequency bands. Further experimental paradigms are now needed to investigate this suggestive hypothesis.
The Time Course of Word Category Ambiguity Processing: an MEG study. (.pdf, 1.45MB)
During my intership at the F.C. Donders Centre for Cognitive Neuroimaging in Nijmegen, I worked on an MEG experiment on ambiguous word processing. Participants were presented, one word at the time, with a sentence which contained a word which could be read as a noun or as a verb. For example, I train every day versus I miss the train. However, we used Dutch, which is much more flexible than English. The ambiguous word was in the 3rd, 4th or 5th position and sentences were constructed in such a way that both (noun/verb) readings were still plausible and equally likely.
We analyzed the MEG signal with both ERFs (Event-related fields, the MEG equivalent of the ERPs) and time-frequency analysis. Results showed that oscillatory activity (in the 20-22 Hz frequency band), but not ERF amplitude, increased when participants read the ambiguous word. However, when the following word, which always disambiguated the meaning of the ambiguous sentence, appeared, we found no changes in the oscillatory activity, but a clear ERF amplitude increase for the ambiguous sentence in comparison to a non-ambiguous control one.
Diagrams and Representation of Reality in C.S. Peirce
During my Bachelor's thesis, I studied how diagrams can represent the reality so faithfully. There is little in common between a house and a sketch of it on paper. Nevertheless, architects and construction workers use this sketch to construct a perfectly solid house. How does a single piece of paper convey so much information, more than our language can?
Based on the work of C.S. Peirce, I investigated what the house and its sketch have in common. Peirce calls it iconicity, roughly defined as the similarity between the sign (the sketch) and its reference (the house). Although intuitively clear, the idea of iconicity in Peirce plays a major role in determining and creating reality, seen as the product of a converging and always-refining process (Scholastic Realism).